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  • Title: Chlamydia trachomatis infection does not enhance local cellular immunity against concurrent Candida vaginal infection.
    Author: Kelly KA, Gray HL, Walker JC, Rank RG, Wormley FL, Fidel PL.
    Journal: Infect Immun; 2001 May; 69(5):3451-4. PubMed ID: 11292774.
    Abstract:
    Although Th1-type cell-mediated immunity (CMI) is the predominant host defense mechanism against mucosal Candida albicans infection, CMI against a vaginal C. albicans infection in mice is limited at the vaginal mucosa despite a strong Candida-specific Th1-type response in the draining lymph nodes. In contrast, Th1-type CMI is highly effective against an experimental Chlamydia trachomatis genital tract infection. This study demonstrated through two independent designs that a concurrent Candida and Chlamydia infection could not accelerate or modulate the anti-Candida CMI response. Together, these results suggest that host responses to these genital tract infections are independent and not influenced by the presence of the other.
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