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  • Title: Time-course and clinical value of the urine trypsinogen-2 dipstick test in acute pancreatitis.
    Author: Pezzilli R, Morselli-Labate AM, d'Alessandro A, Barakat B.
    Journal: Eur J Gastroenterol Hepatol; 2001 Mar; 13(3):269-74. PubMed ID: 11293447.
    Abstract:
    OBJECTIVE: Urine trypsinogen-2 has been suggested as a marker of damage due to acute pancreatitis. Our aim was to assess the time-course and the clinical value of this test in acute pancreatitis. METHODS: A urine trypsinogen-2 dipstick test was performed on 30 patients with acute pancreatitis upon admission to the emergency room, as well as on 30 patients with non-pancreatic acute abdominal pain, and in 30 healthy subjects. RESULTS: In 53.3% of the patients with acute pancreatitis the dipstick test showed abnormal urine trypsinogen-2 whereas this test gave negative results in all patients with non-pancreatic acute abdomen and in all healthy subjects. Patients with severe acute pancreatitis had a frequency of abnormal results of urine trypsinogen-2 (8/9, 88.9%; 95% CI, 51.8-99.7%) significantly higher (P = 0.031) than those with the mild disease (8/21, 38.1%; 95% CI, 18.1 -61.6%), while no significant differences were found in the urine trypsinogen-2 results between patients with biliary acute pancreatitis and those with non-biliary acute pancreatitis. Regarding the time-course of urine trypsinogen-2, there were no significant differences during the three days of the study. CONCLUSIONS: The specificity of urine trypsinogen-2 in the diagnosis of acute pancreatitis is good however its sensitivity is low.
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