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  • Title: [Application of chromosome painting technique to analysis of structural aberration of human chromosomes].
    Author: Yang H, Song Y, Liu Q, Li Y, Fu S, Zhang G, Li P.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2001 Apr; 18(2):135-8. PubMed ID: 11295135.
    Abstract:
    OBJECTIVE: This study was aimed at using chromosome painting technique to detect translocation, especially microtranslocations, on chromosomes in comparison with G-banding analysis. METHODS: Chromosome painting technique was applied to analysis of metaphase chromosomes of patients for detecting translocations with biotin-labeled chromosomes X, Y, 14q, 10 specific probes. RESULTS: Fluorescence in situ hybridization FISH signals were shown clearly in slides even in specimen stored at room temperature for 10 years and at -80 centigrade degree. Translocations were located precisely. CONCLUSION: Microtranslocations, which are hard to analyze by G-banding, can be detected exactly using chromosome painting technique with G-band karyotype on metaphase chromosome.
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