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  • Title: Lipiodol solution of a lipophilic agent, (188)Re-TDD, for the treatment of liver cancer.
    Author: Jeong JM, Kim YJ, Lee YS, Ko JI, Son M, Lee DS, Chung JK, Park JH, Lee MC.
    Journal: Nucl Med Biol; 2001 Feb; 28(2):197-204. PubMed ID: 11295430.
    Abstract:
    Radiolabeled lipiodol has been used for targeting liver cancer. We developed a lipiodol solution of (188)Re-TDD (2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol) and investigated its feasibility for the treatment of liver cancer. The lipiodol solution of (188)Re-TDD was well-retained in the lipiodol phase in vitro. After injection through the tail veins of mice, high lung-uptake was investigated which is evidence of embolizing activity. We also found high accumulation in hepatoma after injection through the hepatic arteries of hepatoma-bearing rats. In conclusion, the lipiodol solution of (188)Re-TDD is a promising agent for liver cancer therapy.
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