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  • Title: Actin-based motility: stop and go with Ena/VASP proteins.
    Author: Reinhard M, Jarchau T, Walter U.
    Journal: Trends Biochem Sci; 2001 Apr; 26(4):243-9. PubMed ID: 11295557.
    Abstract:
    Proteins of the Ena/VASP (Enabled/vasodilator-stimulated phosphoprotein) family are involved in Abl and/or cyclic nucleotide-dependent protein kinase signaling pathways. These proteins are also crucial factors in regulating actin dynamics and associated processes such as cell-cell adhesion, platelet function and actin-based motility of both cytopathogenic Listeria and their eukaryotic host cells. Although biochemical mechanisms have emerged depicting Ena/VASP proteins as enhancers of actin filament formation, increasing evidence also suggests that these proteins have inhibitory functions in integrin regulation, cell motility and axon guidance.
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