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  • Title: Mucocutaneous presence of cytomegalovirus associated with human immunodeficiency virus infection: discussion regarding its pathogenetic role.
    Author: Daudén E, Fernández-Buezo G, Fraga J, Cardeñoso L, García-Díez A.
    Journal: Arch Dermatol; 2001 Apr; 137(4):443-8. PubMed ID: 11295924.
    Abstract:
    OBJECTIVES: To investigate the significance of cytomegalovirus (CMV) in mucocutaneous lesions in patients with human immunodeficiency virus (HIV), and to elucidate its pathogenetic role in lesions genesis. DESIGN: Retrospective (study 1) and prospective (studies 2 and 3) surveys. SETTING: Departments of Dermatology, Pathology, and Microbiology at a university hospital in Madrid, Spain. PATIENTS: Seventeen HIV-infected patients with CMV presenting any type of mucocutaneous lesions (study 1); 27 HIV-positive patients with mucocutaneous vesicles and/or ulcers of any type and location (study 2); and 12 severely immunosuppressed HIV-positive volunteers (study 3). INTERVENTIONS: Mucocutaneous biopsy specimens from the lesions (studies 1 and 2) and from nonlesional skin (study 3) were analyzed by light microscopy, immunohistochemical analysis, and microbiological analysis (standard viral culture and shell-vial technique). MAIN OUTCOME MEASURES: Clinical data; histologic, immunohistochemical, and microbiological findings. RESULTS: (1) Studies 1 and 2: Most of the lesions where CMV was found were ulcers localized mainly on perianal, genital, and perigenital areas, usually as part of polymicrobial infections, particularly herpes simplex and varicella-zoster virus infections. The finding of CMV was confirmed in all cases by light microscopy; microbiological analysis was rarely useful. The finding of mucocutaneous CMV inclusions allowed their early detection in extracutaneous locations. (2) Study 3: Cytomegalovirus was present on healthy skin of the perianal area in 3 patients, and on the forearm in 1 patient. CONCLUSION: Cytomegalovirus does not play any significant pathogenetic role at least in most of the cutaneous lesions where it is found.
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