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  • Title: [Diagnosis of primary Sjogren's syndrome].
    Author: Gran JT, Myklebust G.
    Journal: Tidsskr Nor Laegeforen; 2001 Feb 20; 121(5):563-6. PubMed ID: 11301610.
    Abstract:
    BACKGROUND: The diagnosis of primary Sjögren's syndrome largely depends on pathological findings at lower lip biopsy, or the presence of anti SSA and/or anti SSB antibodies. The present study evaluated which clinical and laboratory features among patients with sicca symptoms could predict a positive biopsy. MATERIAL AND METHODS: All 217 patients evaluated for sicca symptoms at Aust-Agder Central Hospital, Arendal, Norway from 1989 through 1998 were retrospectively reviewed. RESULTS: 136 biopsies were performed. 59 patients were diagnosed with primary Sjögren's syndrome. A reduced Schirmer I test combined with either an elevated ESR, positive ANA or elevated serum gammaglobulin had a high positive predictive value for primary Sjögren's syndrome. INTERPRETATION: Among patients with sicca symptoms, those with laboratory evidence of inflammation, autoimmunity or exocrine dysfunction should be subjected to a lower lip biopsy for a final diagnosis of primary Sjögren's syndrome.
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