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  • Title: [Combination therapy of antibiotics and intravenous immunoglobulin].
    Author: Masaoka T.
    Journal: Nihon Rinsho; 2001 Apr; 59(4):781-4. PubMed ID: 11305006.
    Abstract:
    A large scale multicenter randomized controlled study was conducted to evaluate the efficacy of intravenous immunoglobulin in combination with IPM/CS and AMK in 504 evaluable patients who did not respond by 3 day therapy with beta-lactum and aminoglucoside. Immunoglobulin 5 g was administered 3 days to the patients allocated to immunoglobulin group. A completely automatic computer evaluation was performed according to the criteria determined by the committee. The response rate was 61.5% in immunoglobulin group and 47.3% in control group(p < 0.001). Intravenous immunoglobulin is considered effective for severe infection when used as combination therapy with antibiotics.
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