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  • Title: Early (N70m) neuromagnetic signal topography and striate and extrastriate generators following pattern onset quadrant stimulation.
    Author: Tzelepi A, Ioannides AA, Poghosyan V.
    Journal: Neuroimage; 2001 Apr; 13(4):702-18. PubMed ID: 11305898.
    Abstract:
    The MEG signal generated by sinusoidal grating pattern onset at 1 and 3 cpd, presented randomly to the four quadrants, was analyzed in terms of gross signal properties and current dipole modeling and for a subset of subjects with magnetic field tomography (MFT). In all subjects a prominent wave was identified with a peak latency around 70 ms (N70m), modulated by spatial frequency and varying systematically with the stimulation quadrant. Sensors over occipital areas recorded stronger responses with lower field quadrants, while the signal for sensors a few centimeters more superior was stronger with upper quadrant stimuli. A strong signal in inferior occipitotemporal areas was less sensitive to upper and lower field stimulation and was stronger in the left hemisphere with contralateral (right) visual field stimulation. For lower visual field stimulation a good fit to the average data was obtained with a single dipole for 3 cpd, but was less consistent across run repetitions for 1 cpd. Neither the single-dipole model nor the two-dipole model produced a good fit across runs with the upper field stimuli. MFT solutions identified overlapping activity in striate and extrastriate areas in all conditions. The MFT solutions in the V1/V2 at the N70m were highly reproducible across run repetitions for 1 and 3 cpd, and consistent with the cruciform model, even though they were often weaker than simultaneously activated extrastriate generators. Extrastriate generators in V5 and the human homologue of V6, which were variable across run repetitions at N70m, settled to highly reproducible activations between 100 and 200 ms.
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