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  • Title: Integrin-associated protein (CD47) and its ligands.
    Author: Brown EJ, Frazier WA.
    Journal: Trends Cell Biol; 2001 Mar; 11(3):130-5. PubMed ID: 11306274.
    Abstract:
    Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRP alpha and a component of a supramolecular complex containing specific integrins, heterotrimeric G proteins and cholesterol. Peptides containing a VVM motif in the C-terminal domain of thrombospondins are agonists for CD47, initiating heterotrimeric Gi protein signaling that augments the functions of integrins of the beta 1, beta 2 and beta 3 families, thus modulating a range of cell activities including platelet activation, cell motility and adhesion, and leukocyte adhesion, migration and phagocytosis.
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