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  • Title: Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase.
    Author: Berge DL, De Ridder M, Verovski VN, Janssens MY, Monsaert C, Storme GA.
    Journal: Br J Cancer; 2001 Apr 20; 84(8):1122-5. PubMed ID: 11308264.
    Abstract:
    Chronic hypoxia up-regulated the mRNA and protein expression of inducible nitric oxide synthase (iNOS) in EMT-6 tumour cells exposed to interferon (IFN)-gamma and interleukin (IL)-I beta. Low concentrations of cytokines (1 unit ml(-1)) in 1% but not in 21% oxygen induced a remarkable increase in NO production and a 1.8-fold hypoxic cell radiosensitization. Therefore, chronic hypoxia may potentially be exploited to increase tumour cell radioresponse through the cytokine-inducible iNOS pathway.
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