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  • Title: Changes in the T cell receptor macromolecular signaling complex and membrane microdomains during T cell development and activation.
    Author: Leitenberg D, Balamuth F, Bottomly K.
    Journal: Semin Immunol; 2001 Apr; 13(2):129-38. PubMed ID: 11308296.
    Abstract:
    Initiation and propagation of T cell receptor signaling pathways involves the mobilization and aggregation of a variety of signaling intermediates with the T cell receptor and associated molecules into specialized signaling complexes. Accumulating evidence suggests that differential regulation of the formation and composition of the T cell receptor macromolecular signaling complex may affect the different biological consequences of T cell activation. The regulatory mechanisms involved in the assembly of these complexes remains poorly understood, but in part is affected by the avidity of the T cell receptor ligand, co-stimulatory signals, and by the differentiation state of the T cell.
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