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  • Title: [Endometrial adenocarcinoma appearing during tamoxifen therapy. Report of a clinical case].
    Author: Menada MV, Corticelli A, Giannesi A, Nicoletti L, Podesta M, Rissone R, Fulcheri E.
    Journal: Minerva Ginecol; 2000 Dec; 52(12):521-6. PubMed ID: 11310150.
    Abstract:
    Tamoxifen is a non-steroid estrogenic antagonist, used in post-surgical therapy of breast cancer. It interferes with endocrinous promotion of breast cancer. Tamoxifen could determine endometrial, even carcinomatous, alterations. The case of a postmenopausal patient surgically treated for breast cancer and successively treated with tamoxifen (20 mg/die), is reported. She underwent ultrasonographic and hysterosonographic endometrial evaluation and finally a hysterectomy with bilateral annessiectomy. This case seems to confirm tamoxifen possible carcinogenical effects on the endometrium.
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