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  • Title: [Alcoholic lesions of the liver (morphology and several questions concerning pathogenesis)].
    Author: Lebedev SP, Potekaeva MA, Mukhin AS.
    Journal: Arkh Patol; 1975; 37(2):54-62. PubMed ID: 1131059.
    Abstract:
    On the basis of morphological studies of 130 puncture material of the liver in 100 patients with chronic alcoholism the three morphological forms of its lesion were identified: dystrophic changes in hepacytes; alcoholic hepatitis (acute and chronic); cirrhosis of the liver. It is suggested that the morphological forms mentioned above represent the stages of one process--developing alcoholic hepatopathy. Progressing of the process in the liver in chronic alcoholism is connected with necroses of hepacytes as a result of toxic effect of alcohol with a subsequent reaction of the cells of the portal stroma and sinusoids. Gravity of lesions of the liver depends largerly on individual sensitivity to alcohol, one of the main factor of which may be the capacity of the liver to reproduce ADG.
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