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  • Title: Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice.
    Author: Moldrich RX, Beart PM, Jane DE, Chapman AG, Meldrum BS.
    Journal: Neuropharmacology; 2001 Apr; 40(5):732-5. PubMed ID: 11311902.
    Abstract:
    The 3,4-dicarboxyphenylglycines (3,4-DCPG) inhibit sound-induced seizures in DBA/2 mice with the racemate being notably more potent than either isomer (ED(50) (nmol, i.c.v.)): (RS)-3,4-DCPG (0.004; 86 mg/kg, i.p.)>>the mGlu(8) agonist (S)-3,4-DCPG (0.11)>the AMPA antagonist (R)-3,4-DCPG (0.38). A potentiation of anticonvulsant activity between AMPA and mGlu(8) receptors was confirmed by combining (R)-3,4-DCPG with the mGlu(8) agonist (RS)-4-phosphonophenylglycine. This potentiating mechanism provides a novel strategy for the treatment of epileptic seizures.
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