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  • Title: The transfer of galactose from UDP-galactose to endogenous lipid acceptors in liver microsomes.
    Author: Zatta P, Zakim D, Vessey DA.
    Journal: Biochim Biophys Acta; 1975 Jun 12; 392(2):361-5. PubMed ID: 1131367.
    Abstract:
    When the microsomal fraction of beef liver is incubated with UDP-[14-C]-galactose in the presence of an inhibitor of nucleotide pyrophosphatase, there is an incorporation of the [14-C]galactose into glycoprotein and into two lipid components, one soluble in chloroform and the other in chloroform/methanol/water (1:1:0.3). Chromatography of the chloroform fraction on DEAE-cellulose or Kieselguhr G gives a single peak with behavior identical to that of dolichol phosphate mannose. Hydrolysis of the chloroform fraction released free galactose. It seems, therefore, that galactose, like glucose, mannose, and N-acetylglucosamine, can be transferred from its respective sugar nucleotide to glycoprotein via dolichol intermediates.
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