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  • Title: Effect of nifedipine on proliferation and DNA synthesis of human gingival fibroblasts.
    Author: Sun W, Jiang C, Zheng S.
    Journal: Chin J Dent Res; 2000 Dec; 3(4):49-53. PubMed ID: 11314088.
    Abstract:
    OBJECTIVE: To investigate the effect of Nifedipine, a calcium channel blocker, on cellular proliferation in gingival fibroblasts in vitro. METHODS: Gingival fibroblasts were cultured and incubated with various concentrations of Nifedipine (23.5, 108, 360, and 1200 ng/mL) for up to 7 days. RESULTS: Cell numbers were significantly different among these groups on the sixth and seventh days, especially between the 1200 ng/mL or 360 ng/mL and the other concentrations. CONCLUSION: Nifedipine can influence proliferation of gingival fibroblasts in high concentrations.
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