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  • Title: Persistence of vibrissal motor representation following vibrissal pad deafferentation in adult rats.
    Author: Franchi G.
    Journal: Exp Brain Res; 2001 Mar; 137(2):180-9. PubMed ID: 11315546.
    Abstract:
    The effect of sensory vibrissal pad denervation on M1 organization was studied in adult rats 2 weeks after the infraorbital nerve was severed. Cortical motor output organization was assessed mapping the representation size and thresholds of vibrissa movements evoked by intracortical electrical microstimulation (ICMS). Motor cortex output patterns of control and sham groups of rats were compared with those of rats that had received unilateral or bilateral infraorbital nerve lesions. The mean size of the vibrissa representation in both unilateral and bilateral input-deprived hemispheres was not significantly different from those in control and sham hemispheres. The mean threshold required to evoke vibrissa movements was significantly higher in both groups of deafferented hemispheres than in control and sham groups of hemispheres. In contrast, the mean threshold required to evoke other types of movements from both groups of input-deprived hemispheres were similar to those found in the control and sham groups of hemispheres. These results indicate that input-deprived vibrissal motor representation reflects lower-than-normal excitability, although the size and topographic relationship with neighboring representations are normal.
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