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  • Title: Localization of polycyclic hydrocarbon carcinogens in the lung following intratracheal instillation in gelatin solution.
    Author: Kennedy AR, Little JB.
    Journal: Cancer Res; 1975 Jun; 35(6):1563-7. PubMed ID: 1131823.
    Abstract:
    The deposition and localization of benzo(a)pyrene (BP) suspended in a gelatin-0.9 percent NaCl solution was studied in hamster lungs by ultraviolet fluorescence microscopy. BP was deposited primarily in the alveolar region of the lung. Although large numbers of BP-filled macrophages were seen in the upper airways by 24 hr after an instillation, little BP appeared to penetrate into the bronchial epithelium. The intratracheal instillation of polycyclic hydrocarbons in a gelatin-0.9 percent NaCl solution appears to be a useful model when it is desired to deliver the carcinogen dose to the peripheral lung.
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