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  • Title: [Sickle cell anemia and pregnancy: considerations on systematic prophylactic transfusion].
    Author: Salque C, Berrebi A, Alie-Daram S, Ayoubi JM, Rigal-Huguet F.
    Journal: J Gynecol Obstet Biol Reprod (Paris); 2001 Apr; 30(2):160-5. PubMed ID: 11319468.
    Abstract:
    Sickle cell anemia, a congenital hemolytic type of anemia due to a genetic defect in the beta chain of the globin molecule can cause severe disease. During pregnancy, the risk for preeclampsia and deep venous thrombosis is increased in patients with sickle cell anemia. Occlusion of placenta blood vessels with rigid deformed erythrocytes can cause repeated miscarriages and intra-uterine fetal death. Repeated blood transfusions can prevent these complications by reducing the concentration of abnormal hemoglobin S. We report on the evolution of five pregnancies in three patients with sickle cell anemia who received multiple blood transfusions during gestation, and discuss advantages and risks involved in the care of such cases.
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