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Title: Subjective visual halos after sildenafil (Viagra) administration: Electroretinographic evaluation. Author: Gabrieli CB, Regine F, Vingolo EM, Rispoli E, Fabbri A, Isidori A. Journal: Ophthalmology; 2001 May; 108(5):877-81. PubMed ID: 11320016. Abstract: PURPOSE: The ophthalmologic and electroretinographic (ERG) findings in one subject with subjective visual disturbances after sildenafil administration are described. DESIGN: Interventional case report. METHODS: A complete ophthalmologic examination was performed, including best-corrected visual acuity and ERG, repeated 1 and 2 hours after administration of 100 mg of sildenafil. MAIN OUTCOME MEASURES: Rod responses were obtained over a range of retinal illuminances from those producing a minimum detectable response to those producing rod saturation. Intensity amplitude function was determined. RESULTS: At 2 hours after 100 mg of oral sildenafil, we observed significant variations from baseline in parameters of best-fit Naka-Rushton function; V(max) was notably higher, and K was 0.14 log units lower than baseline. CONCLUSIONS: Sildenafil administration resulted in a higher rod response to light stimuli and in a higher rod sensitivity. These findings are consistent with the weak PDE-6 inhibition induced by sildenafil.[Abstract] [Full Text] [Related] [New Search]