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  • Title: [Preoperative use of nonsteroidal anti-infective agents (NSAID) in treatment of postoperative pain].
    Author: Kostarczyk M, Zabicka A, Machalica A, Kuśnierczyk R.
    Journal: Pol Merkur Lekarski; 2001 Jan; 10(55):12-5. PubMed ID: 11320542.
    Abstract:
    The purpose of the investigation was to evaluate the application of NSAiD before the surgical procedure and its impact on pain sensation and the amount of opioids and other analgetics administered to patient during the postoperation period. 60 patients had been operated on choledocholithiasis and iguinal haemia. 20 of those patients were operated on cholelithiasis by using conventional method i.e. laparotomy, while 20 others had laparoscopic cholecystectomy. All these patients received general anesthesia. Another 20 patients had performed herniotomy using Schouldice method. They received subarachnoid blockade. Each group was devided at random into two subgroups consisting of 10 people each. One of them was administered 3 doses of NSAiD during 24 h before scheduled operation and the other was given placebo. To evaluate the intensity of pain the following parameters were used: visual analgetic scale (VAS), breath frequency, lung vital capacity, and total dose of opioids and other analgetics used during first and second day after procedure. Only patients who had been applied the same method of surgical treatment were compared. All the parameters, mainly VAS and the total dose of analgetics differed. The most visible difference was in the group of patients operated conventionally on cholelithiasis. Preemptive administration of NSAiD is justified, specially in patients before laparotomy.
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