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  • Title: Fas-FasL in Hashimoto's thyroiditis.
    Author: Stassi G, Zeuner A, Di Liberto D, Todaro M, Ricci-Vitiani L, De Maria R.
    Journal: J Clin Immunol; 2001 Jan; 21(1):19-23. PubMed ID: 11321234.
    Abstract:
    Hashimoto's thyroiditis is a common chronic autoimmune disease characterized by the loss of thyroid follicular cells (thyrocytes) that are gradually replaced by lymphocytic infiltration and diffuse fibrosis. These morphological findings suggested that autoreactive T-cell clones were responsible for thyrocyte destruction and hypothyroidism through effector-target cytotoxic recognition. Later, autonomous interaction between thyrocyte Fas and FasL has been proposed as a major mechanism of thyrocyte depletion in Hashimoto's thyroiditis. Here, we analyze the possible role of Fas and FasL in the pathogenesis of Hashimoto's thyroiditis. We suggest that the Fas-FasL system dictates the outcome of the autoimmune response by acting on both immune and target cells.
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