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  • Title: Biphasic manner of melittin on isolated guinea pig atria.
    Author: Yang S, Liu JE, Zhang AZ, Jiang MH.
    Journal: Acta Pharmacol Sin; 2000 Mar; 21(3):221-4. PubMed ID: 11324419.
    Abstract:
    AIM: To investigate the effect of melittin (Mel) on isolated guinea pig atria. METHODS: The effect of Mel on the contraction and heart rate of isolated guinea pig atria at different concentrations was determined. RESULTS: Mel at a lower concentration (0.1-0.8 mumol.L-1) enhanced the contraction of left atria in a concentration-dependent manner; but at a higher concentration (1.6-12.8 mumol.L-1) it exerted an inhibitory effect. At 0.1-30 mumol.L-1 it was found to increase heart rate of right atria. In addition, verapamil (Ver) 0.3 mumol.L-1 was found to depress the effect of Mel. CONCLUSION: Mel possesses a biphasic effect on left atria and a positive chronotropic effect on right atria. Its mechanism might be related with Ca2+ channel.
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