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  • Title: Seroprevalence of human herpesvirus-6 in healthy population in two provinces of north China.
    Author: Wu Z, Mu G, Wang L.
    Journal: Chin Med Sci J; 1997 Jun; 12(2):111-4. PubMed ID: 11324495.
    Abstract:
    BACKGROUND: Human herpesvirus-6 (HHV-6) infection is ubiquitous in selected population with seroprevalence of 60-80%. Little is known for that in China, except few sporadic studies. To understand prevalence of HHV-6 antibody in Chinese population, this seroepidemiological study was conducted. METHODS: Sera were collected from 430 healthy persons and donors living in North China, and tested for HHV-6 antibodies using IFA with HHV-6 GS strain passaged on HSB-2 cells as antigen, and titer equal or higher than 1:10 was regarded as seropositive. RESULTS: Of the 430 serum samples tested, 297 (69.1%) were positive for HHV-6 IgG. Both seropositive rate and GMT in females were significantly higher than those in males, with X2 = 7.05, P < 0.01 and F = 7.23, P < 0.01, respectively. Statistically significant difference in prevalence of HHV-6 antibody among various age groups was observed in both sexes, with X2 = 20.08 and 20.28, P = 0.04, respectively, and young children had a higher titer than adults. But, no significant difference in prevalence was observed in blood donors between various age groups or both sexes. CONCLUSIONS: This study suggests that HHV-6 infection with seropositive IgG is ubiquitous in North China, and its importance should be further studied.
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