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  • Title: Molecular aspects of HLA class II alphabeta heterodimers associated with IDDM susceptibility and protection.
    Author: Ettinger RA, Nepom GT.
    Journal: Rev Immunogenet; 2000; 2(1):88-94. PubMed ID: 11324697.
    Abstract:
    HLA-DQ alleles are strongly associated with IDDM susceptibility and protection. Studies assessing the molecular properties of HLA-DR, a HLA class II locus in linkage disequilibrium with HLA-DQ, have made substantial contributions toward elucidating the structure and function of HLA class II molecules. Reports on the molecular properties of HLA-DQ are now following and have revealed interesting observations regarding the stability of HLA-DQ alphabeta heterodimers. Future work is expected to provide an understanding of the mechanism by which HLA-DQ is associated with IDDM susceptibility and protection.
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