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  • Title: Diagnosis of concurrent hemoglobin H disease and heterozygous beta-thalassemia.
    Author: Ma ES, Chan AY, Au WY, Yeung YM, Chan LC.
    Journal: Haematologica; 2001 Apr; 86(4):432-3. PubMed ID: 11325652.
    Abstract:
    Definitive diagnosis of concurrent hemoglobin (Hb) H disease and heterozygous beta-thalassemia cannot be made from Hb analysis alone, but necessitates genotype analysis and family study. Interactions between alpha- and beta-thalassemia must be considered when investigating moderate to severe hypochromic microcytic anemia of uncertain cause in adult patients from areas with a high prevalence of globin gene mutations.
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