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Title: [Expression of integrin beta 3 and intracellular adhesion molecule in endometrium and endometriotic tissue]. Author: Wu J, Zhang J, Liu Y. Journal: Zhonghua Fu Chan Ke Za Zhi; 1999 Apr; 34(4):204-6. PubMed ID: 11326914. Abstract: OBJECTIVE: To study the relationship between integrin beta 3, intracellular adhesion molecule (ICAM) and endometriosis. METHODS: The expression of integrin beta 3 and ICAM protein were determined in 3 batches by immunoblotting method in 15 endometrium and 15 endometriotic tissues of patients with endometriosis and 30 endometrium from non-endometriosis subjects during the same menstrual phase. The results were scanned and semi-quantified, and then analysed by F test and t test. RESULTS: The results from 3 measurements showed the same trend. Endometrium from patients with endometriosis expressed significantly fewer integrin beta 3 and ICAM protein than those without endometriosis. On the other hand, the expression of integrin beta 3 in endometriotic tissue was significantly lower while the ICAM expression was significantly higher than those in controls. CONCLUSIONS: In patients with endometriosis, integrin beta 3 and ICAM expression changed significantly from eutopic to ectopic endometrium which may be related to the development of endometriosis and infertility.[Abstract] [Full Text] [Related] [New Search]