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  • Title: 1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors.
    Author: Sabb AL, Vogel RL, Kelly MG, Palmer Y, Smith DL, Andree TH, Schechter LE.
    Journal: Bioorg Med Chem Lett; 2001 Apr 23; 11(8):1069-71. PubMed ID: 11327592.
    Abstract:
    Amino acid derivatives of 1,2,5-thiadiazol-3-yl-piperazine related to (+)-WAY-100135 and WAY-100635 are potent 5-HT1A receptor agonists and antagonists, which have selective affinity for 5-HT1A receptors versus alpha1 and dopamine (D2, D3, and D4) receptors.
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