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Title: Compensatory adaptations of skeletal muscle composition to a long-term functional overload. Author: Hubbard RW, Ianuzzo CD, Mathew WT, Linduska JD. Journal: Growth; 1975 Mar; 39(1):85-93. PubMed ID: 1132777. Abstract: Compensatory hypertrophy of rat plantaris muscle was induced by ablating the synergistic gastrocnemius muscle. The sham-operated contralateral muscle served as a control. Within 5, 30 and 60 days postoperatively, the wet weight of the hypertrophied plantaris was 40, 64, and 109% greater, respectively, than the contralateral control. Two patterns of changing muscle composition emerged with compensatory hypertrophy: (1) an early (less than or equal to 5 days) increase in DNA content (+190%) which resulted in a sharp decline in the wet weight per nucleus ratio (-50%). This coincided with an increase in sarcoplasmic and stromal proteins and a fall in myofibrillar protein concentration. These changes were followed by (2) a secondary increase (30-60 days postoperatively) in the proportions of myofibrillar proteins with a corresponding decline in sarcoplasmic proteins.[Abstract] [Full Text] [Related] [New Search]