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  • Title: Successful ribavirin therapy for life-threatening laryngeal papillomatosis post liver transplantation.
    Author: Balauff A, Sira J, Pearman K, McKiernan P, Buckels J, Kelly D.
    Journal: Pediatr Transplant; 2001 Apr; 5(2):142-4. PubMed ID: 11328555.
    Abstract:
    A 3-yr-old girl developed severe progressive juvenile laryngeal papillomatosis (JLP) 2 yr after liver transplantation (Tx) for biliary atresia. The papillomata were resistant to withdrawal of immunosuppression, to laser surgery, and to subcutaneous interferon (3 MU/m2, three times weekly), necessitating tracheostomy. Oral ribavirin therapy (25 mg/kg/day) in combination with no immunosuppression effectively prevented the rapid recurrence of JLP over 5 yr. Hence, oral ribavirin is a potentially useful therapy in this life-threatening situation and may also be of benefit in other children with severe JLP.
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