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  • Title: Breast cancer genetics: what we know and what we need.
    Author: Nathanson KL, Wooster R, Weber BL.
    Journal: Nat Med; 2001 May; 7(5):552-6. PubMed ID: 11329055.
    Abstract:
    Breast cancer results from genetic and environmental factors leading to the accumulation of mutations in essential genes. Genetic predisposition may have a strong, almost singular effect, as with BRCA1 and BRCA2, or may represent the cumulative effects of multiple low-penetrance susceptibility alleles. Here we review high- and low-penetrance breast-cancer-susceptibility alleles and discuss ongoing efforts to identify additional susceptibility genes. Ultimately these discoveries will lead to individualized breast cancer risk assessment and a reduction in breast cancer incidence.
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