These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Role of mononuclear phagocyte system in hemopoiesis regulation in AKR/JY mice during preleukemic period.
    Author: Stavrova LA, Dygai AM, Zhdanov VV, Gol'dberg ED, Tkachenko SB.
    Journal: Bull Exp Biol Med; 2001 Jan; 131(1):41-3. PubMed ID: 11329079.
    Abstract:
    Feeder activity of bone marrow adherent cells and peritoneal macrophages is decreased and colony-stimulating and erythropoietic activity of unfractionated bone marrow increased in highly leukemic AKR/JY mice in comparison with CBA/CaLac mice. At the same time maturation of hemopoietic precursor cells in AKR/JY mice is delayed compared to controls. This indicates compensatory activation of nonadherent elements of the hemopoiesis-inducing microenvironment against the background of suppressed activity of adherent elements. Hence, leukemogenic virus produced a systemic damage to target cells (e.g. mononuclear phagocyte system), which probably represent a mechanism of leukemic transformation in AKR/JY mice.
    [Abstract] [Full Text] [Related] [New Search]