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  • Title: Metabolic significance and expression of Caenorhabditis elegans type II 3-oxoacyl-CoA thiolase.
    Author: Bun-ya M, Maebuchi M, Togo SH, Kurosawa T, Hashimoto T, Kamiryo T.
    Journal: Cell Biochem Biophys; 2000; 32 Spring():291-3. PubMed ID: 11330061.
    Abstract:
    The authors cloned the cDNA of the nematode Caenorhabditis elegans encoding a 44-kDa protein (P-44), which is similar to sterol carrier protein x (SCPx). Genomic DNA data and Northern blot analysis excluded the possibility of P-44 forming SCPx-like fusion protein. P-44 is required in the formation of bile acid in vitro from CoA esters of their enoyl-form intermediate in the presence of D-3-hydroxyacyl-CoA dehydratase/D-3-dehydrogenase bifunctional protein. Also, rat SCPx converts 24-hydroxy-form intermediate to bile acid under similar conditions. From this and other evidence, P-44 and SCPx were categorized as type II thiolase. The mRNA encoding P-44 was detected in every developmental stage of C. elegans: egg, larval stages, and adult. P-44, therefore, seems essential for the normal functioning of this organism.
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