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  • Title: Identification of a novel member of the T1R family of putative taste receptors.
    Author: Sainz E, Korley JN, Battey JF, Sullivan SL.
    Journal: J Neurochem; 2001 May; 77(3):896-903. PubMed ID: 11331418.
    Abstract:
    In the gustatory system, the recognition of sugars, amino acids and bitter-tasting compounds is the function of specialized G protein-coupled receptors. Recently, two members of novel subfamily of G protein-coupled receptors were proposed to function as taste receptors based on their specific expression in taste receptor cells. Here, we report the identification of a third member, T1R3, of this family of receptors. T1R3 maps near the telomere of mouse chromosome 4 rendering it a candidate for the Sac locus, a primary determinant of sweet preference in mice. Consistent with its candidacy for the Sac locus, T1R3 displays taste receptor cell-specific expression. In addition, taster and non-taster strains of mouse harbor different alleles of T1R3.
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