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  • Title: [Acute lymphoblastic leukemia with Philadelphia chromosome: eight case reports].
    Author: Laatiri MA, Chehata S, Amouri A, Sendi HS, Saad A, Ennabli S.
    Journal: Tunis Med; 2001 Jan; 79(1):38-41. PubMed ID: 11332342.
    Abstract:
    Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) is an aggressive form of acute leukemia that children ALL. Between 1991 and 1998, eight cases Ph+ ALL (7 males and one female) were diagnosed in our institution by successful cytogenetic studies. Median age was 37 years (range, 1-60 years). Leukocyte count was more than 50 x 109/l in 5 cases. According to the French-American-British (FAB) criteria, six patients were classified L1 and two L2. The Ph+ as sole anomaly was seen in 2 patients (25%), while additional chromosome changes were observed in 6 cases. Complete remission was achieved in 5 cases (62%) and relapse was observed in all cases? The 2-year survival rae was 25% confirming the worse prognosis of this leukemia when treated with standard chemotherapy.
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