These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Increased polyploid incidence is associated with abnormal copper accumulation in the liver of LEC mutant rat.
    Author: Muramatsu Y, Yamada T, Moralejo DH, Mochizuki H, Sogawa K, Matsumoto K.
    Journal: Res Commun Mol Pathol Pharmacol; 2000; 107(1-2):129-36. PubMed ID: 11334362.
    Abstract:
    Long-Evans Cinnamon (LEC) rats are deleted at the p-type copper transport ATPase gene (Atp7b), so that they exhibit abnormal hepatic copper concentration. In this study, it was confirmed that LEC rat liver possesses a feature of increase in polyploid. Furthermore, a segregation analysis using backcrosses between LEC and F344 normal rats showed that the increased polyploid incidence is strongly associated with excessive copper content in their liver. These results should demonstrate that copper cytotoxicity leads to the impairment of mitotic progression, resulting in the increase of polyploid in the liver of LEC rats.
    [Abstract] [Full Text] [Related] [New Search]