These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Gastrointestinal stromal tumor with a novel mutation of KIT proto-oncogene.
    Author: Fukuda R, Hamamoto N, Uchida Y, Furuta K, Katsube T, Kazumori H, Ishihara S, Amano K, Adachi K, Watanabe M, Kinoshita Y.
    Journal: Intern Med; 2001 Apr; 40(4):301-3. PubMed ID: 11334388.
    Abstract:
    The majority of human gastrointestinal mesenchymal tumors are gastrointestinal stromal tumors (GISTs). Recent reports have shown the existence of gain-of-function mutations in the juxta-membrane domain of receptor tyrosine kinase (KIT) in GISTs. We present a 77-year-old woman with GIST diagnosed by positive immunostaining of cluster designation (CD) 34 and KIT. This case had a novel mutation at codon 576 located in the juxta-membrane domain of KIT. Our results indicate the importance of mutations in this KIT region and suggest the possibility of the existence of other types of mutations in this region in GISTs.
    [Abstract] [Full Text] [Related] [New Search]