These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Motor discoordination in mutant mice heterozygous for the type 1 inositol 1,4,5-trisphosphate receptor.
    Author: Ogura H, Matsumoto M, Mikoshiba K.
    Journal: Behav Brain Res; 2001 Aug 01; 122(2):215-9. PubMed ID: 11334652.
    Abstract:
    In the brain, the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) is a major subtype of receptors for inositol 1,4,5-trisphosphate, which mediates the release of calcium from intracellular stores. The motor function of knockout mice heterozygous for IP3R1 (IP3R1+/-) was assessed. An impairment of motor coordination was observed in IP3R1+/- mice in the rotating rod test. There was no observable difference between genotypes in spontaneous motor activity, grip strength, the hanging test, or walking pattern. These results suggest that IP3R1 plays a substantial role in motor coordination.
    [Abstract] [Full Text] [Related] [New Search]