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  • Title: Solubility of nonelectrolytes in polar solvents III: Alkyl p-aminobenzoates in polar and mixed solvents.
    Author: Yalkowsky SH, Amidon GL, Zografi G, Flynn GL.
    Journal: J Pharm Sci; 1975 Jan; 64(1):48-52. PubMed ID: 1133705.
    Abstract:
    The relative solubilities of n-alkyl p-aminobenzoates in water, proplyene blycol-water mixtures, proplyene glycol, and several other pharmaceutically important solvents can be predicted on the basis of a theoretical equation. This equation relates the activity coefficient of the hydrophobic portion of the molecule to the product of its surface area and its interfacial tension [free energy per unit area of a hydrocarbon (tetradecane) against the polar or semipolar solvent of interest]. The assumptions, conclusions, and applicability of the theorectical relationship are compared to those of the Scatchard-Hildebrand approach.
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