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  • Title: Spectrophotometric determination of manidipine dihydrochloride based on formation of charge-transfer complex with iodine.
    Author: De Laurentis N, Losacco V, Milillo MA, Zarrilli A.
    Journal: Boll Chim Farm; 2001; 140(1):15-9. PubMed ID: 11338771.
    Abstract:
    A new spectrophotometric method for determining manidipine dihydrochloride has been developed. The method was based on the formation of charge transfer complex between this drug as n-donor and iodine the s-acceptor. The iodine was found to form charge-transfer complex in a 1:1 stoichiometry with absorption bands at 290 and 353 nm. Conformity to Beer's law enabled the assay of dosage forms of this drug, the concentration range for the best accuracy is 3-11 micrograms/ml. The method can be applied successfully to the analysis of commercially available manidipine dihydrochloride tablets.
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