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  • Title: Acute iliac vein thrombosis in pregnancy treated successfully by streptokinase lysis: a case report.
    Author: Henrich W, Schmider A, Henrich M, Dudenhausen JW.
    Journal: J Perinat Med; 2001; 29(2):155-7. PubMed ID: 11344675.
    Abstract:
    BACKGROUND: Postthrombotic syndrome is an important late complication after deep vein thrombosis in pregnancy. Thrombolytic agents are more efficient in preventing this condition but are rarely used in pregnant women. CASE: A 22-year-old woman at 29 weeks of gestation presented with acute iliac vein thrombosis. After application of a heparin bolus, systemic streptokinase lysis was performed. Low-dose heparin therapy was continued for the remainder of the, otherwise unremarkable, pregnancy. Spontaneous delivery of a healthy girl was without complications and thromboprophylaxis with low-molecular heparin was continued. CONCLUSION: Thrombolysis in pregnancy is possible and may help to prevent severe long-term sequelae of thrombosis in young women. Bleeding is a major risk, which must be considered and therapy should only be administered under close observation.
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