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  • Title: [Chronic myelogenous leukemia with marked thrombocytosis].
    Author: Hasegawa T, Hino M, Yamane T, Ota K, Takubo T, Kitagawa S, Tatsumi N.
    Journal: Rinsho Ketsueki; 2001 Mar; 42(3):199-203. PubMed ID: 11345782.
    Abstract:
    We report a case of chronic myelogenous leukemia (CML) with marked thrombocytosis. The patient was a 68-year-old woman who showed marked thrombocytosis (> 200 x 10(4)/microliter), a slightly increased leukocyte count without any immature myeloid cells in the peripheral blood, and no hepatosplenomegaly. Philadelphia chromosome (Ph) was detected by karyotype analysis and FISH. The bcr-abl transcript was detected by RT-PCR and the break point was located in the major bcr. Treatment with interferon-alpha was effective, reducing the proportion of Ph-positive cells from 56% to 7% within 21 months. Detailed study of atypical cases of CML such as the present one may provide additional information about the disease pathogenesis.
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