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  • Title: [Skin toxicity associated with bolus infusion of low-dose cytarabine].
    Author: Takeuchi M, Tanizawa A, Fukumoto Y, Kikawa Y, Mayumi M.
    Journal: Rinsho Ketsueki; 2001 Mar; 42(3):216-7. PubMed ID: 11345785.
    Abstract:
    A 4-year-old boy with ALL received low-dose ara-C (50 mg/m2/day, bolus). After 10 fractions of ara-C, he developed an erythematous rash predominantly on the palms and soles, mimicking acral erythema except for the absence of pain. Chemotherapy was interrupted and the rash disappeared in four days. A similar rash occurred again just after the second cycle of ara-C had been started. Co-administration of dexamethasone improved the rash rapidly, thus allowing the chemotherapy to be continued, and suggesting the beneficial effect of corticosteroids. Although skin toxicity induced by low-dose ara-C is very rare and usually occurs after continuous infusion, it should also be borne in mind when considering bolus infusion.
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