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  • Title: Evaluation of esterified hyaluronic acid as middle ear-packing material.
    Author: Li G, Feghali JG, Dinces E, McElveen J, van de Water TR.
    Journal: Arch Otolaryngol Head Neck Surg; 2001 May; 127(5):534-9. PubMed ID: 11346429.
    Abstract:
    OBJECTIVE: To evaluate the efficacy of esterified hyaluronic acid (MeroGel) as a middle ear (ME)-packing material. DESIGN: Randomized controlled trial. MATERIAL: Twenty-four guinea pigs. INTERVENTION: Group 1, MeroGel-treated animals (n = 10), bilateral wounding of ME mucosa with 5 of the animals receiving the MeroGel packing in the left ME and 5 of the animals receiving MeroGel in the right ME; group 2, absorbable gelatin sponge-treated animals (n = 10), with the same experimental protocol as in group 1 except that the absorbable gelatin sponge was the packing material; group 3, untreated animals (n = 4), unilateral wounding of the left ME mucosa in 2 animals and in 2 animals in the right ME, with no packing material. Auditory brainstem recordings were performed for all groups before the ME operation and 5 days and 6 weeks after the operation. RESULTS: Auditory brainstem response recordings at postoperative day 5 showed that all ears with ME packing had hearing losses in the frequency range of 500 to 4000 Hz. The recovery of hearing acuity at postoperative week 6 was significantly better in group 1 (MeroGel-treated) guinea pigs compared with group 2 (the absorbable gelatin sponge-treated) animals. In group 2 animals, 20% of the packing material remained in the ME cavities and new bone formation was observed, while in group 1 animals, there was less packing material in the ME and no formation of new bone. CONCLUSIONS: MeroGel is a nonototoxic packing material with a high level of biocompatibility for ME mucosa; it is an effective supportive material following ME surgery and is easily expelled from the ME cavity.
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