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  • Title: Differences in energy metabolism and neuromuscular transmission between 30-Hz and 100-Hz stimulation in rat skeletal muscle.
    Author: Takata S, Ikata T.
    Journal: Arch Phys Med Rehabil; 2001 May; 82(5):666-70. PubMed ID: 11346845.
    Abstract:
    OBJECTIVE: To examine differences in energy metabolism and neuromuscular transmission failure in rat hindlimb muscles subjected to electric stimulation at different frequencies. DESIGN: Experimental animal study. SETTING: Bioenergetic Research Center at Otsuka Pharmaceutical Company, Otsuka, Japan. ANIMALS: Thirty-two 25-week-old male Wistar-Kyoto rats. INTERVENTIONS: With the rat under general anesthesia, the sciatic nerve was electrically stimulated at 30Hz and 100Hz to induce muscle contraction. MAIN OUTCOME MEASURES: Energy level and intracellular pH of muscles by phosphorus-31 magnetic resonance spectroscopy ((31)P-MRS); M-wave amplitude of muscles by electromyography. RESULTS: During the first 4 minutes under stimulation at 30Hz and at 100Hz, energy level and intracellular pH dropped to their lowest values (p <.05 or p <.01); the values then recovered with time. Recovery rates of energy level and intracellular pH during stimulation at 100Hz were greater than those observed during stimulation at 30Hz. The M-wave amplitude during 100-Hz stimulation was permanently and significantly lower than that measured during 30-Hz stimulation (p <.01), and the recovery rate of M-wave amplitude after stimulation at 100Hz was slower than that after stimulation at 30Hz. CONCLUSION: Neuromuscular transmission failure was greater with 100-Hz stimulation than with 30-Hz stimulation. This finding may account for the rapid recovery of energy level and intracellular pH that occurs with stimulation at 100Hz.
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