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  • Title: Genetic and biochemical studies of mutants of Penicillium chrysogenum impaired in penicillin production.
    Author: Normansell PJ, Normansell ID, Holt G.
    Journal: J Gen Microbiol; 1979 May; 112(1):113-26. PubMed ID: 113485.
    Abstract:
    Seventy-eight mutants of Penicillium chrysogenum strain NRRL 1951, that were impaired in penicillin production, were isolated following treatment with various mutagens. Twelve that yielded about 10% of their parental penicillin titre were studied in detail. Analyses of heterozygous diploids formed between them revealed the existence of at least five complementation groups with respect to penicillin production--V, W, X, Y and Z. Most mutants belonged to group Y. A biochemical investigation of the intracellular peptides in strains representing the five groups demonstrated the absence of the tripeptide alpha-aminoadipoylcysteinyl-valine from mutants of groups X, Y and Z. Extracts of mutants of groups W, Y and Z were able to catalyse a penicillin acyl-exchange reaction, a mutant of group V showed only a trace of activity and mutant from group X completely lacked this ability.
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