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  • Title: Pyrogenicity and cytokine-inducing properties of Streptococcus pyogenes superantigens: comparative study of streptococcal mitogenic exotoxin Z and pyrogenic exotoxin A.
    Author: Müller-Alouf H, Proft T, Zollner TM, Gerlach D, Champagne E, Desreumaux P, Fitting C, Geoffroy-Fauvet C, Alouf JE, Cavaillon JM.
    Journal: Infect Immun; 2001 Jun; 69(6):4141-5. PubMed ID: 11349089.
    Abstract:
    Streptococcal mitogenic exotoxin Z (SMEZ), a superantigen derived from Streptococcus pyogenes, provoked expansion of human lymphocytes expressing the Vbeta 2, 4, 7 and 8 motifs of T-cell receptor. SMEZ was pyrogenic in rabbits and stimulated the expression of the T-cell activation markers CD69 and cutaneous lymphocyte-associated antigen. A variety of cytokines was released by human mononuclear leukocytes stimulated with SMEZ, which was 10-fold more active than streptococcal pyrogenic exotoxin A. Th2-derived cytokines were elicited only by superantigens and not by streptococcal cells.
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