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  • Title: H+,K+-ATPase is not involved in endolymph pH homeostasis.
    Author: Couloigner V, Teixeira M, Bozorg-Grayeli A, Friedlander G, Sterkers O, Ferrary E.
    Journal: Acta Otolaryngol; 2001 Jan; 121(2):122-4. PubMed ID: 11349761.
    Abstract:
    In endolymph, the calculated electrochemical gradients suggest the presence of active transport of H+ and K+. The presence of H+,K+-ATPase, an active transporter that mediates the exchange of intracellular H+ for extracellular K+, was investigated using reverse transcription-polymerase chain reaction on rat microdissected inner ear tissues. Distal colon and kidney were used as positive controls. The two H+,K+-ATPase colonic or gastric isoforms were not detected in the rat cochlea and endolymphatic sac. This result suggests that H+,K+-ATPase is not involved in H+ and K+ endolymph homeostasis.
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