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  • Title: Expression of multidrug efflux pump SmeDEF by clinical isolates of Stenotrophomonas maltophilia.
    Author: Alonso A, Martinez JL.
    Journal: Antimicrob Agents Chemother; 2001 Jun; 45(6):1879-81. PubMed ID: 11353642.
    Abstract:
    The presence of the multidrug efflux pump SmeDEF was assessed in a collection of clinical isolates of Stenotrophomonas maltophilia. All isolates encoded this pump, as demonstrated by PCR. Forty-seven percent of the strains overproduced a protein of the same size that was immunoreactive against an anti-SmeF antibody, and 33% overexpressed the gene semD when they were tested by reverse transcription-PCR. A correlation between smeDEF overexpression and antibiotic resistance was observed.
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